Pioneering Regenerative Medicine
Without Immunosuppression
Pioneering Regenerative Medicine
Without Immunosuppression
iTOL-100:
Biotechnology-Derived Protein Inducing
Immune Tolerance Platform
iTOL-100 is a synthetic form of the naturally occurring protein, FasL, combined with a synthetic biotin-PEG microgel (SA-FasL microgel) that allows convenient and effective co-administration with implanted cells or organoids to induce local immune tolerance without the need for life-long immunosuppression.
iTOL-100:
Biotechnology-Derived Protein Inducing
Immune Tolerance Platform
iTOL-100 is a synthetic form of the naturally occurring protein, FasL, combined with a synthetic biotin-PEG microgel (SA-FasL microgel) that allows convenient and effective co-administration with implanted cells or organoids to induce local immune tolerance without the need for life-long immunosuppression.
Developing a Potential Cure for Type 1 Diabetes
Our lead program iTOL-102 combines our iTOL-100 technology with an inexhaustible supply of insulin producing allogeneic stem cell-derived pancreatic islets and is being developed as a potential cure for Type 1 Diabetes. In a pre-clinical non-human primate study, allogenic pancreatic islet cells co-implanted with SA-FasL microgel exhibited long-term function with control of blood glucose levels and restoration of insulin secretion without the use of chronic immune suppression.
Development Pipeline
We Were 1 of 3 Companies Selected to Participate in the
Disruptive Healthcare Technology Showcase at the US Capital
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Kadimastem and iTolerance Complete Initial Targeted Engagement for Regulatory Advice on CBER Products (INTERACT) Meeting with the U.S. FDA
Companies Advancing Joint Clinical Development of a Potential Cure for Diabetes Without the Need for Chronic Suppression of the Immune System Ness Ziona, Israel, January 22, 2024, Kadimastem (TASE: KDST) and iTolerance Inc. announced today that the companies held a...
iTolerance, Inc. to Present at Biotech Showcase™ 2024
Live presentation on Monday, January 8th at 11:30 AM PTMIAMI, FL / January 4, 2024 / iTolerance, Inc. ("iTolerance" or the "Company"), an early-stage, privately-held biotechnology company focused on the development of innovative regenerative medicines, today announced...
iTolerance, Inc. to Present at Biotech Showcase(TM) 2024
Live presentation on Monday, January 8th at 11:30 AM PT MIAMI, FL / January 4, 2024 / iTolerance, Inc. ("iTolerance" or the "Company"), an early-stage, privately-held biotechnology company focused on the development of innovative regenerative medicines, today...