About
Highly motivated Biomedical Engineer leveraging strong analytical abilities…
Activity
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The team is kicking off Day 1 of MD&M West in Anaheim! 👟 Drop by booth #1442 and let's chat about sensor integration for your upcoming projects…
The team is kicking off Day 1 of MD&M West in Anaheim! 👟 Drop by booth #1442 and let's chat about sensor integration for your upcoming projects…
Liked by Timothy Boire
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Congratulations to Timothy Boire and Geoffrey Lucks of VenoStent, Inc. on this massive milestone. It has been a joy to be a part of your journey of…
Congratulations to Timothy Boire and Geoffrey Lucks of VenoStent, Inc. on this massive milestone. It has been a joy to be a part of your journey of…
Liked by Timothy Boire
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Great writeup by Alice Levitt of Houston's InnovationMap about the beginning of our US Clinical Trial. Our gratitude to the Innovation Map team for…
Great writeup by Alice Levitt of Houston's InnovationMap about the beginning of our US Clinical Trial. Our gratitude to the Innovation Map team for…
Liked by Timothy Boire
Experience
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Education
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Vanderbilt University
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Activities and Societies: Society for Biomaterials, Biomedical Engineering Society, Life Science Tennessee, American Heart Association, American Institute of Mechanical Engineering
-Coursework in Quantitative Methods, Physics, Biostatistics, Signals and Systems, Programming, Cell and Molecular Biology, Human Physiology, Imaging Modalities, Microscopy, Polymer Science and Engineering, Drug Delivery, Research and Professional Development, and Responsible Research Conduct.
-Enrolled in Business Innovation, a two semester experiential learning course where my dissertation work will be featured with a team of business school and law students. Multidisciplinary issues…-Coursework in Quantitative Methods, Physics, Biostatistics, Signals and Systems, Programming, Cell and Molecular Biology, Human Physiology, Imaging Modalities, Microscopy, Polymer Science and Engineering, Drug Delivery, Research and Professional Development, and Responsible Research Conduct.
-Enrolled in Business Innovation, a two semester experiential learning course where my dissertation work will be featured with a team of business school and law students. Multidisciplinary issues involved in taking fundamental research projects to the market will be examined. Issues explored will include patterns of technological change, identifying market and technological opportunities, competitive market analysis, the process of technology commercialization, intellectual property protection, and methods of valuing new technology.
-Dissertation work involves medical device development based on novel materials that I helped develop -
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Activities and Societies: American Institute of Chemical Engineers (AIChE), International Society for Pharmaceutical Engineering (ISPE)
-BS in Chemical & Biological Engineering with a second major in Biotechnology
-Participated in 3 different research projects at Tufts involving cell culture work in an abdominal aortic aneurysm model, methanol fuel cell development, and biomimetic microfluidic device design to examine liver toxicity effects.
-Collaborated with other undergraduate students, graduate students, and faculty on these projects to successfully complete design work.
-Served as Vice President of the AICHE and…-BS in Chemical & Biological Engineering with a second major in Biotechnology
-Participated in 3 different research projects at Tufts involving cell culture work in an abdominal aortic aneurysm model, methanol fuel cell development, and biomimetic microfluidic device design to examine liver toxicity effects.
-Collaborated with other undergraduate students, graduate students, and faculty on these projects to successfully complete design work.
-Served as Vice President of the AICHE and ISPE Tufts Chapters in 2006-08.
-Assisted in design of a hybrid racecar as a member of the Tufts Hybrid Racecar Team.
Publications
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Effect of Pore Size and Spacing on Neovascularization of a Biodegradable Shape Memory Polymer Perivascular Wrap
Journal of Biomedical Materials Research Part A
See publicationNeointimal hyperplasia (NH) is a main source of failures in arteriovenous fistulas and vascular grafts. Several studies have demonstrated the promise of perivascular wraps to reduce NH via promotion of adventitial neovascularization and providing mechanical support. Limited clinical success thus far may be due to inappropriate material selection (e.g., nondegradable, too stiff) and geometric design (e.g., pore size and spacing, diameter). The influence of pore size and spacing on implant…
Neointimal hyperplasia (NH) is a main source of failures in arteriovenous fistulas and vascular grafts. Several studies have demonstrated the promise of perivascular wraps to reduce NH via promotion of adventitial neovascularization and providing mechanical support. Limited clinical success thus far may be due to inappropriate material selection (e.g., nondegradable, too stiff) and geometric design (e.g., pore size and spacing, diameter). The influence of pore size and spacing on implant neovascularization are investigated here for a new biodegradable, thermo‐responsive shape memory polymer (SMP) perivascular wrap. Following an initial pilot, 21 mice were each implanted with six scaffolds: four candidate SMP macroporous designs (A‐D), a nonporous SMP control (E), and microporous GORETEX (F). Mice were sacrificed after 4 (N = 5), 14 (N = 8), and 28 (N = 8) days. There was a statistically significant increase in neovascularization score between all macroporous groups compared to nonporous SMP (p < 0.023) and microporous GORETEX (p < 0.007) controls at Day 28. Wider‐spaced, smaller‐sized pore designs (223 μm‐spaced, 640 μm‐diameter Design C) induced the most robust angiogenic response, with greater microvessel number (p < 0.0114) and area (p < 0.0055) than nonporous SMPs and GORETEX at Day 28. This design also produced significantly greater microvessel density than nonporous SMPs (p = 0.0028) and a smaller‐spaced, larger‐sized pore (155 μm‐spaced, 1,180 μm‐sized Design B) design (p = 0.0013). Strong neovascularization is expected to reduce NH, motivating further investigation of this SMP wrap with controlled pore spacing and size in more advanced arteriovenous models.
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Tunable Surface Repellency Maintains Stemness and Redox Capacity of Human Mesenchymal Stem Cells
ACS Applied Materials & Interfaces
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Biomaterial-Based Approaches to Address Vein Graft and Hemodialysis Access Failures
Macromolecular Rapid Communications
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Copolymer-mediated Cell Adhesion Promotes a Pro-Angiogenic Stem Cell Phenotype in vitro and in vivo
Advanced Healthcare Materials
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Noncovalent Pi-Pi Stacking at the Carbon-Electrolyte Interface: Controlling the Voltage Window of Electrochemical Supercapacitors
ACS Applied Materials & Interfaces
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Current Progress in Nanotechnology Applications for Diagnosis and Treatment of Kidney Diseases
Advanced Healthcare Materials
Other authors -
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Engineering integrative stem cell and biomaterial therapies for peripheral artery disease
Frontiers in Biomedical Engineering: Converging Technology, Biosystems & Biorobotics
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Pendant Allyl Crosslinking as a Tunable Shape Memory Actuator for Vascular Applications
Acta Biomaterialia
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Decoupling Polymer Properties to Elucidate Mechanisms Governing Cell Behavior
Tissue Engineering Part B: Reviews
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ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response
J. Mater. Chem. B, 2014,2, 7109-7113
Patents
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Temperature-Responsive Polymer Compositions and Methods of Use
Filed US 20160024249
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Development and Vascular Applications of Shape Memory External Stents
US WO2016/168706A1
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Shape Memory Polymer Compositions and Methods of Use
US 14/318,179
Projects
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TechVenture Challenge - 2013
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Led a team that developed a business plan for a technology that has been developed at Vanderbilt University.
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Honors & Awards
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1st Place, Owen Business Plan Competition
Vanderbilt Owen Graduate School of Management
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2nd Place, Competing Round Flight 2, 2016 Rice Business Plan Competition
Rice Business Plan Competition
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Finalist, TERMIS World Congress Meeting Poster Competition
Tissue Engineering and Regenerative Medicine International Society (TERMIS)
Was one of 25 finalists selected for the competition over greater than 1200 total posters admitted for the TERMIS World Congress Meeting in Boston, MA September 8 - 11, 2015
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2nd Place, 2015 AUTM Fishbowl Fights Business Pitch Competition
Association of Technology Managers (AUTM)
$1,000 cash prize for 2nd place at the AUTM Central Region Meeting Fishbowl Fights competition. The 4 judges were local VCs
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American Heart Association Predoctoral Fellowship Awardee
American Heart Association
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Student Travel Award Recognition (STAR), 2015 Society for Biomaterials Annual Meeting
Society for Biomaterials
Based on the outstanding quality of the abstract:
"A Shape Memory External Support to Improve Vein Patency" -
VICTR Grant Award
Vanderbilt Institute for Clinical and Translational Research
$10,000 to fund the project, "A shape memory external stent to reduce dialysis graft failure"
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NSF Innovations Corps (I-Corps) Award
National Science Foundation
$50K grant for business model generation and customer discovery activities with PI Hak-Joon Sung, Co-PI Colleen Brophy, and Business Mentor Byron Smith, CEO of EndoInsight
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2nd Place, 2013 Master's Student Paper Competition
ASME Summer Bioengineering Conference
For the work, "Development of a Shape Memory Patch for Minimally Invasive Repair of Vascular Injury"
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2nd Place, Coulter College Business Competition, Biomedical Engineering Society
Biomedical Engineering Society
More activity by Timothy
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Big congrats to Timothy Boire and Geoffrey Lucks on the first US implant of the VenoStent, Inc. Device!
Big congrats to Timothy Boire and Geoffrey Lucks on the first US implant of the VenoStent, Inc. Device!
Liked by Timothy Boire
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We're excited to welcome Albert Huang, MD, to Pioneer Fund as a Venture Partner! A general surgery-trained founder of Y Combinator company ALLOTROPE…
We're excited to welcome Albert Huang, MD, to Pioneer Fund as a Venture Partner! A general surgery-trained founder of Y Combinator company ALLOTROPE…
Liked by Timothy Boire
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We have been working hard for almost a year... I'm excited to announce the 1st Closing of the Wealthing VC Fund. #venturecapital…
We have been working hard for almost a year... I'm excited to announce the 1st Closing of the Wealthing VC Fund. #venturecapital…
Liked by Timothy Boire
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Thanks for the shoutout The Innovation Space!
Thanks for the shoutout The Innovation Space!
Liked by Timothy Boire
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VenoStent, Inc. is also hiring a temporary Engineering Intern/Co-Op position for Fall 2023 to help with our device manufacturing and lab-based…
VenoStent, Inc. is also hiring a temporary Engineering Intern/Co-Op position for Fall 2023 to help with our device manufacturing and lab-based…
Liked by Timothy Boire
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I'm excited to share that I'll be joining VenoStent, Inc. this summer as a Product Development Engineer Intern. I am grateful for the unwavering…
I'm excited to share that I'll be joining VenoStent, Inc. this summer as a Product Development Engineer Intern. I am grateful for the unwavering…
Liked by Timothy Boire
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“Work-life balance” is a misnomer, implying they should be given equal weight, with a “balance” between the two. Instead, work is just a part of…
“Work-life balance” is a misnomer, implying they should be given equal weight, with a “balance” between the two. Instead, work is just a part of…
Liked by Timothy Boire
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