Pioneering Regenerative Medicine
Without Immunosuppression

We are a data-driven and patient-centric regenerative medicine company working to enable implantable tissue, organoid or cell therapy without the requirement for life-long immunosuppression. Leveraging our proprietary technology platform, we are advancing a pipeline of product candidates that have the potential to cure diseases.

Pioneering Regenerative Medicine
Without Immunosuppression

We are a data-driven and patient-centric regenerative medicine company working to enable implantable tissue, organoid or cell therapy without the requirement for life-long immunosuppression. Leveraging our proprietary technology platform, we are advancing a pipeline of product candidates that have the potential to cure diseases.

iTOL-100:

Biotechnology-Derived Protein Inducing
Immune Tolerance Platform

iTOL-100 is a synthetic form of the naturally occurring protein, FasL, combined with a synthetic biotin-PEG microgel (SA-FasL microgel) that allows convenient and effective co-administration with implanted cells or organoids to induce local immune tolerance without the need for life-long immunosuppression.

iTOL-100:

Biotechnology-Derived Protein Inducing
Immune Tolerance Platform

iTOL-100 is a synthetic form of the naturally occurring protein, FasL, combined with a synthetic biotin-PEG microgel (SA-FasL microgel) that allows convenient and effective co-administration with implanted cells or organoids to induce local immune tolerance without the need for life-long immunosuppression.

Developing a Potential Cure for Type 1 Diabetes

Our lead program iTOL-102 combines our iTOL-100 technology with an inexhaustible supply of insulin producing allogeneic stem cell-derived pancreatic islets and is being developed as a potential cure for Type 1 Diabetes. In a pre-clinical non-human primate study, allogenic pancreatic islet cells co-implanted with SA-FasL microgel exhibited long-term function with control of blood glucose levels and restoration of insulin secretion without the use of chronic immune suppression.

Development Pipeline

We Were 1 of 3 Companies Selected to Participate in the
Disruptive Healthcare Technology Showcase at the US Capital

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iTolerance, Inc. to Present at Biotech Showcase™ 2024

Live presentation on Monday, January 8th at 11:30 AM PTMIAMI, FL / January 4, 2024 / iTolerance, Inc. ("iTolerance" or the "Company"), an early-stage, privately-held biotechnology company focused on the development of innovative regenerative medicines, today announced...

iTolerance, Inc. to Present at Biotech Showcase(TM) 2024

Live presentation on Monday, January 8th at 11:30 AM PT MIAMI, FL / January 4, 2024 / iTolerance, Inc. ("iTolerance" or the "Company"), an early-stage, privately-held biotechnology company focused on the development of innovative regenerative medicines, today...