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More rapid, automated, and complete myeloid genomic profiling
Myeloid testing should be fast. However, myeloid malignancy samples can be challenging to analyze. They are complex, heterogeneous, and have the potential to proliferate rapidly. To get meaningful genetic insights, you need a rapid and streamlined approach for studying all key mutations.
The Impact of Fast NGS Molecular Profiling in Myeloid Malignancy Research
At EHA 2022, Dr. Dolors Colomer discussed the impact that the Oncomine Myeloid Assay GX had on turnaround times and laboratory efficiency. She presented compelling data on FLT3-ITD, showing 100% concordance between NGS and fragment analysis and the ability to detect low-frequency variants ranging in size from 12–180 bp.
Oncomine Myeloid Assay GX v2
The Ion Torrent Oncomine Myeloid Assay GX V2 on the Ion Torrent Genexus System provides a complete next-generation sequencing (NGS) solution that can deliver a comprehensive myeloid mutational report in as little as 24 hours.
| Rapid | Automated | Comprehensive | Trusted | Insightful |
| Go from specimen to result in as little as one day | Process samples with just 20 minutes of hands-on time required. | Simultaneously profile 45 key genes (DNA) and 34 fusion drivers (RNA), covering >800 unique fusions. | Reliably detect a wide range of variants, including challenging-to-sequence targets like FLT3-ITD. | Get an annotated variant report, including links to latest relevant evidence. |
Profile all key myeloid mutations with one test
Simultaneously interrogate 45 DNA target genes and 34 fusion driver genes (RNA). This broad fusion panel allows you to sequence over 800 unique fusion transcripts. Gene content on the panel has been curated to cover relevant targets for all the major myeloid disorders—AML, MDS, MPN, CML, CMML, and JMML.
| 28 | 17 | 34 | 5 | 5 |
| Hot Spot Genes | Full Genes | Fusion Drivers | Expression Genes | Expression Controls |
Complete coverage of key genes
| HotSpot Genes (28) | Full Genes (17) | Fusion Driver Genes (34) | Expression Genes (5) | Expression Control Genes (5) | |||||
| ANKRD26 | IDH1 | PPM1D | ASXL1 | RB1 | ABL1 | HMGA2 | NUP98 | BAALC | EIF2B1 |
| ABL1 | IDH2 | PTPN11 | BCOR | RUNX1 | ABL2 | JAK2 | NUP214 | MECOM | FBXW2 |
| BRAF | JAK2 | SMC1A | CALR | SH2B3 | BCL2 | KAT6A (MOZ) | PAX5 | MYC | PSMB2 |
| CBL | KIT | SMC3 | CEBPA | STAG2 | BRAF | KAT6B | PDGFRA | SMC1A | PUM1 |
| CSF3R | KRAS | SETBP1 | ETV6 | TET2 | CCND1 | KMT2A (includes PTD) | PDGFRB | WT1 | TRIM27 |
| DDX41 | MPL | SF3B1 | EZH2 | TP53 | CREBBP | MECOM | RARA | ||
| DNMT3A | MYD88 | SRSF2 | IKZF1 | ZRSR2 | EGFR | MET | RUNX1 | ||
| FLT3 (ITD, KTD) | NPM1 | U2AF1 | NF1 | ETV6 | MLLT10 | TCF3 | |||
| GATA2 | NRAS | WT1 | PHF6 | FGFR1 | MRTFA (MKL1) | TFE3 | |||
| HRAS | PRPF8 | FGFR2 | MYBL1 | ZNF384 | |||||
| FUS | MYH11 | ||||||||
| NTRK2 | |||||||||
| NTRK3 | |||||||||
Detect multiple types of mutations at once
Myeloid samples frequently harbor mutations in difficult-to-sequence regions of the genome. The Oncomine Myeloid Assay GX v2 has been carefully engineered to reliably detect all relevant mutations associated with myeloid malignancies, including targets in challenging genes like CEBPA, FLT3, CALR and more.
- Single nucleotide variants
- Insertions and Deletions
- Tandem duplications
- Gene fusions
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It's NGS made easy
A highly integrated workflow lets you go from specimen to report in as little as 20 minutes of hands-on time required. It’s never been easier to implement myeloid NGS testing in your lab.
Automate your workflow from specimen to report
Start with any common myeloid specimen type, including whole blood, bone marrow, or peripheral blood leukocytes. From there, the Genexus System integrates and automates nucleic acid extraction, purification, quantification, library preparation, sequencing, analysis and reporting within a single software ecosystem.
Whole Blood
Peripheral Blood Leukocytes (PBLs)
Bone Marrow
Nucleic acid extraction and quantification
Library preparation
Sequencing
Reporting & analysis
Biomarkers linked to relevant evidence from
public data sources
Clear and concise reports
Ion Torrent Oncomine Reporter is a curated knowledgebase and reporting software that links biomarkers to relevant evidence and enables custom reporting. These tools help simplify the bioinformatics workflow and enable you to focus on finding the biological meaning of your data.
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